Prostate Health
News You can Use
News About Prostate Health
This web site will prove that eating red meat and
natural animal fats while restricting
carbohydrates is not only healthy but will prevent and cure many diseases.
Click here to read the Medical Disclaimer.
PreventDisease.com - Prostate Cancer
Nanoparticulate Delivery of "Suicide DNA" to Murine Prostate and Prostate Tumors - May 23, 2007.
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The Keys to Cancer Prevention is Awesome Health
Cancer is caused by a combination of free radical damage to normal cells and the lack of body building amino acids, fatty acids, vitamins and minerals. One major cause for cancer is believed to be the consumption of hydrogenated vegetable oil (trans fats) in the diet. Cancer is NOT caused by eating animal products and natural saturated fats. Instead, meat and natural fats are just the foods which promote health and prevent cancer because they give one awesome health. The immune system cells that kill cancer cells are made from polypeptides of amino acids. Meat is the best source of amino acids in the protein. Cofactors of vitamins and minerals are also required to make the immune cells. The rate of cancer has risen in all populations that increased their consumption of carbohydrates such as grains and sugars, and factory-made trans fats. Our modern diet as recommended by by the USDA Food Guide Pyramid and other health organizations have replaced meat and healthy animal fats with carbohydrates and inflammatory omega-6 vegetables.
Prostate therapy benefits doubted - May 26, 2006.
Absolute Scientific Proof Carbohydrates Are Pathogenic.
Top Ten Nutritional Myths, Distortions and Lies That Will Destroy Your Heath.
The Cause, Prevention and Spontaneous Remission of Cancer of the Prostate.
Saw palmetto herb 'no aid to prostate health' - April 14, 2006.
Vitamin D boosts cancer treatment - June 14, 2003.
Vitamin D may protect people from developing cancer, according to scientists - August 22, 2000.
Caution on cancer exercise link - BBC News - April 14, 2008.
"The US study found tumours expanded twice as fast in mice given exercise wheels compared to those without."
Cancer cells are gluttons for glucose. Carbohydrates in the diet are broken down during digestion into the basic glucose molecule that enters the blood stream. The cancer cells consume glucose at a higher rate than normal cells which raises the temperature of the cancer cells. Thermal imaging is a technique for finding these higher-temperature cancer cells.
Obviously sugars should be a no-no in the diet for anyone with cancer. They are also bad food for healthy people to eat. Even so, the American Cancer Society (ACS) says people with cancer can eat sugar even though high glycemic food such as sugar has been shown to increase the risk of cancer. Sugar also feeds the existing cancer cells and promotes growth and division. Do not eat any sugar, period. Do not eat sugar in any form because it has a glycemic rating of 100. Sugar raises the level of free-radicals which causes heart disease and diabetes. Do not eat corn syrup, fructose, honey, sucrose, maltodextrin, dextrose, molasses, rice milk, soy milk, grape juice, fruit juice, brown rice syrup, maple syrup, date sugar, cane sugar, corn sugar, beet sugar, succanat or lactose. Do not eat candy, cookies, ice cream, cakes, dates, crackers, soft drinks or yogurt which are all high in carbohydrates. Diabetes, heart disease, stroke, gallstones, cataracts and cancer could best be described as CARBOHYDRATE ADDICTS SYNDROME.
It is a scientific fact that fructose sugar in fruit causes insulin resistance that increases the risk of Alzheimer's disease, heart disease, high blood pressure, cancer and diabetes. See the following truthful study that proves fructose as found in abundance in fruit and fruit juice is one of the root causes for metabolic syndrome, diabetes, heart disease, cancer, inflammatory bowel disease and Alzheimer's disease.
Whole grains are a primary cause of cancer. Whole grains contain molds, fungi, and yeast that have been strongly linked to cancer as discussed below. Whole grains also contain pro-inflammatory omega-6 fatty acids that promote cancer as discussed below. The incidence of cancer in all of the English-speaking world (United States, United Kingdom, Canada and Australia) has exploded in direct proportion to that amount of whole grains eaten in the diet. Cancer is an epidemic that matches the strong consumption of whole grain foods.
Beginning in 1906, arctic explorer Vilhjalmur Stefansson and his companion, Karsen Anderson, spent several years living with Eskimos in Northern Canada. They lived on an all meat and fat diet of seal, polar bear, caribou and fish. Doctors and nutritionists insisted that was impossible. The Eskimos had no carbohydrates and no fiber in their diets but suffered no detectable health effects. In fact, their health was excellent with absolutely no dental caries, no heart disease, no cancer and excellent bone health. To prove his statements were true, both men entered Bellevue Hospital in New York City to live for a full year on a supervised diet of meat and fat only. At the end of the year both men had improvements in health as could be measured by all the tests available at the time.
Stefansson 1 - Eskimos Prove an All Meat Diet Provides Excellent Health.
Many large food manufacturers have lobbied the US Congress and pushed money into newspapers, books, universities, nutritional organizations and medical organizations during the last 60 years to brainwash consumers into believing they should eat the thousands of carbohydrate foods found on the supermarket shelves. As a result the cancer rate has soared. You can test yourself to see the degree of brainwashing that has crept into your thinking. Extensive study and searching are required to get past the lies and distortions of these organizations, politicians and religious vegetarians to reach the facts presented here for your benefit.
The vegetarians of Southern India eat a low-calorie diet very high in carbohydrates and low in protein and fat. They have the shortest life span of any society on Earth, and their bodies have an extremely low muscle mass. They are weak and frail and the children clearly exhibit a failure to thrive. Their heart disease rate is double that of the meat eaters in Northern India. HL Abrams. Vegetarianism: An anthropological/nutritional evaluation. Journal of Applied Nutrition, 1980, 32:2:53-87. The optimal diet for humans can be determined by anthropological research studies that show humans have primarily been meat-eaters. Anthropological Research Reveals Human Dietary Requirements for Optimal Health by H. Leon Abrams, Jr., MA, EDS.
Dr. Tullio Simoncini Cancer Therapy With Sodium Bicarbonate - Cancer Fungus and Candida.
Dr. Tullio Simoncini Successfully Treats Prostate Adenocarcinoma Cancer with Sodium Bicarbonate.
Dr. Tullio Simoncini Successfully Treats Prostate Carcinoma Cancer with Sodium Bicarbonate.
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The Low-Carbohydrate Diet Can Prevent Cancer
1. Eat a low-carbohydrate diet that is high in protein and natural fats as described below.
2. Take two tablespoon per day of Carlson's Lemon Flavored Cod Liver Oil for the essential Omega-3 fatty acids and vitamin D. This is vital for prostate and overall health. Do not take flax seed oil.
Cod Liver Oil: The Number One Superfood.3. Avoid Alpha-Linolenic and Omega-6 Fatty Acids. Some research has indicated that alpha-linolenic acid and total omega-6 fatty acids may increase the risk of prostate cancer. Sources of these fatty acids are the polyunsaturated vegetable oils (e.g., corn, safflower, soybean, canola, and sunflower oil), which constitute the majority of oils consumed in the US.
4. Supplement with selenium, boron and Vitamin E. The Vitamin E must be the natural, mixed-tocopherols type. Synthetic Vitamin E is actually unhealthy.
5. Supplement with zinc which accumulates to the highest levels in a man's body in either a normal prostate or one enlarged from benign prostate hyperplasia (BPH). It may have some protective properties against prostate cancer.
6. Avoid milk and excessive calcium intake.
7. Balance electrolytes with proper mineral intake. Reduce the intake of common table salt, sodium chloride, and use Morton's Salt Substitute, potassium chloride instead. Calcium and magnesium must also be in balance. Take chelated calcium, 1000 mg, and chelated magnesium, 1000 mg, per day. Take some with each meal. These values are for a large male weighing 205 pounds with 20% body fat and should be adjusted for smaller people. Some heart medication require caution with supplemental magnesium. Check with your doctor before using.
8. Supplement with a good overall vitamin, mineral and supplement program. Follow the vitamin, mineral and supplement program list on the following link. Adding colloidal trace minerals to the list of other minerals is extremely important.
My personal vitamin, mineral and supplement program by Kent R. Rieske.9. Avoid all soy products. Soy Danger: Why you should avoid eating Soy.
10. Natural progesterone USP cream can prevent prostate cancer and other problems as well as prevent balding. The cream must be pharmaceutical grade. I use about 5 to 6 mg twice a day, morning and evening, or a total of 10 to 12 mg per day. Apply to the skin and rub in. Apply at a different location on the body each time, arm, leg, shoulder, etc. See the interview with Dr. John R. Lee below.
This web site will prove the most healthy diet for humans is:
70% total fat on a calorie basis
31% saturated fat
7% polyunsaturated fat
25% monounsaturated fat
7% other fats
27% protein
3% carbohydrates (20 gm of which 3 gm or less is fiber).Proof Saturated Fats Are Healthy.
A healthy low-carbohydrate, high-protein diet program has been shown to prevent cancer, heart disease, diabetes, osteoporosis and many other diseases. This diet program can be found on the following web page.
Nutrition, Healing, Health, Protein, Fat, Carbohydrate & Cholesterol Science.
Click here to see the "Foods We Should Eat."
Click here to see the "Foods That Are Absolutely Forbidden."
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Caution! |
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Don't Panic if You
Have Urination Difficulties
Caused by
Benign Prostate Hyperplasia (BPH)
Emergency Procedure You can do at Home for Relieving the Bladder
Doctors commonly suggest that an enlarge prostate suggest a high risk for cancer. The doctor commonly paints a more grave picture when the prostate has irregularities and/or hardness. The doctor will commonly suggest highly invasive and high risk procedures when he feel any signs of lumps, hardness and/or irregularities. The patient may be lead to believe that cancer is a highly probable. This is not the case. Not all lumps, hardness or irregularities are caused by cancer. In fact, cancer may be present within the prostate even thought a digital rectal exam (DRE - or a gloved finger examination through the rectum) indicates a perfectly normal, soft prostate. The is why the DRE has be discredited as a diagnostic method for detecting prostate cancer.
Having some discomfort in urinating caused by BPH can be a better choice than having a medical procedures with the associated high-risk factors. It is a good idea to have a catheter available for relieving the bladder in case of an emergency. The intent is to use them occasionally as needed should urination become difficult or impossible. Catheters can be taken on picnics, vacations, fishing, camping and to work for use as needed. Catheters can be purchased without a doctor's prescription. Some hydrophilic silicone designs come in a sealed package with a pouch of sterile water. The water pouch is broken inside of the package to lubricate the catheter for easy insertion. The catheter is carefully inserted in the penis until it enters the bladder and drains the urine. The catheter is then discarded. Reusing a contaminated catheter can cause a bladder infection. Sizes are generally 16 inches (400 mm) in length with diameters from 10 Fr (French Size, 0.13" or 3.3 mm) to 18 Fr. (0.235" or 6.0 mm). A size 12 Fr is recommended.
Allegro Medical Supplies - Hydrophilic Personal Catheter.Phystosterol Complex with Beta-Sitosterol is a product marketed for the treatment of benign prostate hypertrophy (enlarged prostate). This complex includes beta-sitosterol, the component in Saw Palmetto that is thought to benefit men with an enlarged prostate. However, the effectiveness in treating an enlarged prostate, as is common in elderly men, is questionable. Even so, a nice side effect is its ability to reduce blood pressure. This is a nice combination because many elderly men suffer from both conditions. The product may also be effective for treating hypertension in women who are not pregnant, lactating, hypoglycemic or diabetic. Don't expect a marked reduction in the size of the prostate when supplementing the diet with phystosterol complex with beta-sitosterol. Salesmen and brochures claim you will "pee like a garden hose." This is an absolute lie. It will most likely not help at all.
The prostate surrounds the urethra just below the urethra valve at the outlet of the bladder. The prostate can continue to grow until it interferes with the flow of urine out of bladder. The process of urinating includes relaxing the outlet valve and contracting the bladder. The combination occurs automatically as one relaxes to urinate. The enlarge prostate requires stronger bladder contractions that eventually make the bladder wall thicker. The bladder capacity is reduced as a result making the need to urinate more frequent. The combination of these problems leads to discomfort, inconvenience and a low urine discharge rate.
Treatment Options for Benign Prostate Hyperplasia - Enlarged Prostate
Medical procedures that attempt to correct BPH symptoms can have sever and devastating side effects. The prostate can become chronically infected by bacteria during a needle biopsy procedure in the search for cancer. The needle biopsy is called a core needle biopsy. In this procedure, a larger needle with a cutting edge is used to take a full tissue sample, rather than just sucking out cells. The needle is inserted through the wall of the rectum to reach the prostate. This procedure can push intestinal bacteria into the prostate leading to the infection. Prostate infections can be difficult to cure in many cases. A needle biopsy can increase the spread of cancer by 50 percent. Benign, or non fatal, forms of cancer can be disturbed by a needle biopsy causing the cancer to spread and upgrade to a deadly form. Doctors commonly suggest a core needle biopsy when the prostate has any lumps, irregularities or hardness.
Needle Biopsy Increases the Spread of Cancer by 50 Percent - Part 1
"Tens of thousands of needle biopsies are performed each year in the US alone, and the procedure is universally assumed to be safe and reliable. Yet there is evidence to suggest that needle biopsy may not be as harmless or uncomplicated a procedure as once thought. In fact, it may in some cases inadvertently cause cancer cells to break away from a tumor, thus enabling spread beyond the immediate tumor area."
Needle Biopsy Increases the Spread of Cancer by 50 Percent - Part 2
Increasing the opening in the urethra in the area of the prostate to relieve urination difficulties can cause sever and devastating side effects as well. Sometimes the muscular valve at the outlet of the bladder is accidentally enlarged or damaged. This prevents the ability to hold urine in the bladder. The bladder can leak urine continuously. The patient must resort to wearing an adult diaper or external bag to hold the urine. These serious side effects can be more troublesome than the original condition.
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Your urologist is most likely to destroy your sex life |
Enlarging the urethra in the area of the prostate can damage prostate nerves that are involved in sexual functions. Some patients are rendered impotent and lack the ability to achieve an erection after this procedure. Successful medical procedures without side effects do not exist. Doctors of urology have not succeeded in developing a procedure to relieve BPH urination problems without unacceptable side effects.
| BPH Medical Procedure to Reduce Urination Restriction | Success Rate and Possible Side Effects |
| Transurethral resection of the prostate (TURP) is the most common procedure. Using a viewing instrument called a resectoscope, a hot electrical loop is drawn through the urethra to enlarged the passage at the prostate. The urethra lining is burned away to form a larger flow area. | The success rate in terms of relieving the restriction is good. The possibility that harsh side effects is high. The most common side effect is a condition called retrograde ejaculation, in which semen flows into the bladder rather than out the end of the penis. The infection rate can be high as with any burning method. The outlet valve of the bladder can be destroyed leaving the patient with a chronic lifetime incontinence problem. This requires the patient to wear an adult diaper or urine collection bag. The nerves in the area are destroyed which can lead to impotency (inability to have or maintain an erection). |
| Transurethral incision of the prostate (TUIP) is similar to TURP, this surgery involves widening the urethra by making small cuts in the bladder neck. | The success rate in terms of relieving the restriction is fair. It can be used only when there is minimal enlargement of the prostate. The possible side effects are the same as with the hot wire procedure except the possibility of infection may be reduced slightly. |
| Transurethral microwave thermotherapy (TUMT) is a procedure where a microwave antenna is inserted into the urethra to heat the prostate and destroy overgrown tissue. | Half of all men need additional treatment within four years. The prostate is literally cooked to reduce its growth rate. The long term effects have not be addressed including the possibility of an increase in the incidence of cancer. |
| Transurethral ultrasound-guided laser-induced prostatectomy (TULIP) is a procedure that uses a laser beam to burn off urethra tissue at the prostate under the guidance of ultrasound. | The success rate in terms of relieving the restriction is good, but the list of possible symptoms are about the same as with the hot wire burning method. |
| Open surgery can be used for a very large prostate. An incision is made above the pubic bone to remove tissue from the enlarged prostate. | The success rate in terms of relieving the restriction is good, but all of the risks of open surgery exist. |
| Balloon dilatation uses a balloon catheter that is inserted into the urethra. The balloon is inflated with a saline solution that stretches the urethra and compresses the prostate tissue. | Relief from symptoms after the procedure are only temporary. The problems often return within a few years. However, the side effect risks are low. |
| Prostatic urethral stents are used in the same way as stents used to keep heart arteries open. The mesh cylinders are inserted into the constricted portion of the urethra where they are expanded. | The success rate in terms of relieving the restriction is good, but the possibility of infection and other complications is high. Future removal of the stents require open surgery with all of the associated risk factors. |
| Saw Palmetto is a herbal extract from the Saw palm tree fruit. The tablet is taken on a daily basis. | The success rate at relieving BPH symptoms with Saw Palmetto is extremely variable and has been measured in scientific studies at no more than 20 percent. The side effects are minor. The long term effects have not be addressed including the possibility of an increase in the incidence of cancer. |
| The drug finasteride (Proscar) can shrink the size of the prostate and increase the flow of urine. | Finasteride can take three to six months to
begin working but has been measured as effective in only 20 percent of
men. Some of the serious side effects include: 1. Impotence (inability to have or maintain an erection). 2. Decreased libido (interest in sex). 3. Decreased volume of ejaculate (amount of semen). |
| Alpha-blocker drugs have been used to relax the bladder muscle and increase the ability to urinate. | Symptoms can improve somewhat by taking alpha-blocker drugs, but the bladder muscle is not the primary cause for the urination restriction. An enlarged prostate is the cause and alpha-blockers have no effect on the prostate. Alpha-blockers also cause dizziness, fatigue and excessively low-blood pressure because they are primarily used as a blood pressure lowering medicine. |
Aspartame in diet soft drinks causes increased nighttime urination difficulties in BHP.
Aspartame in diet soft drinks is converted in the body to the amino acid phenylalanine that is the precursor to tyrosine, which, in turn, is the precursor to dopamine and the excitatory neurotransmitters, norepinephrine and epinephrine.
Phenylalanine should be avoided in:
High blood pressure. Has hypertensive properties and should be avoided with people with high blood pressure.
Urination Difficulties Caused by Benign Prostate Hyperplasia (BPH or enlarged prostate).
Pregnancy.
Pigmented melanoma.
PKU (phenylketonuria).
Panic disorder/anxiety attacks.Note:
See Tyrosine. It is more powerful and safer in raising the level of norepinephrine, and thereby treating depression.
Protein and L-Glutamine Drink At Dinner Reduces Nighttime Urination Difficulties
Protein and L-Glutamine Drink. Prepare a drink made with whey amino acid protein powder which is enriched with extra glutamine amino acid. The protein powder consists of a full compliment of amino acid isolates that heal the body and require no digestion. Prepare the drink by blending 8 to 16 oz of reverse osmosis with UV lamp water or unsweetened, low-sodium tomato juice with 1 heaping teaspoon (12 gm) of whey protein powder plus 1 rounded teaspoon (8 gm) of glutamine amino acid powder. Stirring vigorously with the teaspoon is sufficient. The whey protein must be specified on the carton as isolates from cross flow microfiltration and ion-exchange, ultrafiltered concentrate, low molecular weight and partially hydrolyzed whey protein peptides rich in branched chain amino acids and glutamine peptides. The low-carbohydrate type at one gm per scoop or less is best, but it should not be more than four to five gm of carbohydrates per scoop. Do not substitute protein from soy, egg, casein or any other source. Sugar or any other sweetener is unacceptable. Use the "natural flavor" without additives. This amino acid drink can be enjoyed anytime, with or without a meal. Amino acids are food that build and maintain the body. Refrigerate whey protein powder, and discard if it is old. Whey protein powder can cause some gas and can cause an unusual "full" feeling. Discontinue the whey protein powder the if the reactions are unpleasant. Continue to take the glutamine powder.
L-Glutamine Amino Acid.
Ultimate Lo Carb Whey Powder - Natural Flavor by Biochem.
Amino Acids - The Building Blocks of Life and Healing.This combinations amino acids have been shown to provide the following healing properties:
Amino acids are good chelators of positively charged minerals, especially calcium that hardens the arteries.
Provides pain killing effects by healing the nervous system.
Absorption of body building amino acids without requiring digestion.
Stimulates insulin like growth factor 1 (IGF-1) which functions similar to insulin and enhances protein synthesis and healing.
Fights infections by stimulating the immune system. All immune cells are made from poly-peptides of amino acids.
Provides bone growth of protein collagen and strengthens bones. Poor digestion has been shown to cause osteoporosis and degenerative bone disease.
Provides all of the amino acids required to heal and grow ligaments, tendons, joints, muscles, intestinal tract, heart muscle and all other organs of the body.
Prevents hypoglycemia (low blood sugar) symptoms in people with hypoglycemia or diabetes.
Dispelling the Night-Time Frequent Urination Myth
Physicians frequently ask the question about a man's night-time frequency of urination when evaluating his prostate problems. This question seems to imply that the frequency of urination is the result of his prostate being enlarged, and perhaps many physicians believe this is the reason. However, the two may not connect because elderly women who have no prostate can also have the need to go to the bathroom several times during the night. An enlarged prostate can prevent complete emptying of the bladder and increase the frequency of urination, but this is not the major reason for frequent night-time urination.
Fluids tend to accumulate in the legs of both men and women as we get older. This is water in the tissue and is exacerbated by the high-sodium, low-potassium in our modern diet. It can become an obvious symptom of someone with congestive heart disease. Gravity tends to keep the fluid in the lower extremities during the day. While we sleep in the horizontal position the fluids are not held down by gravity and are taken out of the tissue to be dumped in the bladder. This action continues during the night and a person with obvious signs of swelling in the feet or ankles will find the swelling greatly reduced by morning.
The best way to reduce the retention of fluids is to balance the sodium-potassium and calcium-magnesium ratios in the body. This will also reduce the blood pressure and help prevent congestive heart disease. We cannot return to our youthful state, and some fluid retention during the day with frequent urination during the night is inevitable.
Blood Pressure Control, Heart Palpitations, Arrhythmias and Blood Testing.
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Clinical Intervention?
BOSTON, MASSACHUSETTS. Dr. Michael Barry of the Harvard Medical School and the Massachusetts General Hospital provides an excellent review of the current status of PSA screening for prostate cancer. Dr. Barry starts out by posing the question "Should a 65-year-old man with no risk factors for prostate cancer except his age and with a normal digital rectal examination undergo a PSA (prostate-specific- antigen) test?" Dr. Barry points out that whether or not to have a PSA test is controversial because of the following:
No randomized clinical trials have ever demonstrated that early detection and aggressive treatment of prostate cancer reduce mortality;
The treatments usually mobilized after a positive PSA test and biopsy (radical prostatectomy, radiation therapy or castration) are associated with severe side effects including impotence and incontinence.
He also emphasizes that the PSA test is not that accurate. A recent large-scale trial showed that using a cut-off point of 4.0 ng/mL would pick up 46 per cent of cancers that would occur within the next ten years with an accuracy of 91 per cent. The average age of the test group was 63 years. Among older men with benign prostatic hyperplasia (enlarged prostate) the accuracy may be as low as 54 per cent leading to many unneeded biopsies and much unwarranted anxiety. It is estimated that 75 per cent of men undergoing a prostate biopsy because they have PSA levels between 4 and 10 ng/mL do not have cancer. On the other hand, there is also a 10 per cent chance of harbouring cancer even though the biopsy shows nothing.
There are currently at least two large-scale trials underway to determine whether PSA screening is beneficial or harmful overall. However, the results of these trials are not expected until the year 2009. In the meantime Dr. Barry recommends that men aged 50 to 75 years of age (with no established risk factors) should be made aware of the availability of the PSA test and its potential harms and benefits so that they can make an informed choice about having the test. They should receive information on the following points:
the likelihood that prostate cancer will be diagnosed;
the possibilities of false negative and false positive results;
the anxiety associated with a positive test;
the uncertainty regarding whether screening reduces the risk of death from prostate cancer.
Several studies have shown that providing this information significantly reduces the proportion of men who decide to be tested.
Barry, Michael J. Prostate-specific-antigen testing for early diagnosis of prostate cancer. New England Journal of Medicine, Vol. 344, May 3, 2001, pp. 1373-77.
MONTREAL, CANADA. Physicians in North America are becoming increasingly enthusiastic about screening men for prostate cancer. Prostate cancer is now the second most common cancer among Canadian men and is second only to lung cancer in cancer mortality. The two screening tests commonly used are the digital rectal examination (DRE) and the prostate-specific antigen (PSA) blood test. Recently some doctors have been warning against the wholesale use of screening tests. Dr. Kenneth Marshall of the Queen Elizabeth Hospital in Montreal emphasizes that obtaining the patient's informed consent prior to testing is essential. This is because the PSA test in particular often gives a false reading. This can lead to dangerous, invasive biopsies, and subsequent even more dangerous surgery and radiation Prostate cancer operation delay 'safe'ent. It is estimated that 30 per cent of men undergoing radical prostate surgery become impotent, five to six per cent become incontinent and about one per cent die of the operation. Dr. Marshall concludes there is, as yet, no evidence that screening for prostate cancer actually saves lives - a view supported by many European urologists. He also points out that screening and biopsies may actually do more harm than good in cases where the tumor might have remained dormant or only grown very slowly.
Marshall, Kenneth G. Screening for prostate cancer. Canadian Family Physician, Vol. 39, November 1993, pp. 2385-90." Additional information is available at:International Health News - Prostate Cancer Detection
Prostate cancer test overused, study says
Alpha-Methylacyl-CoA Racemase
A New Molecular Marker for Prostate CancerProstate cancer operation delay 'safe'
"Delaying surgery on small, low-grade prostate tumours does not increase the risk of the disease progressing to an incurable form, research suggests. A 10-year study involving 320 men by Baltimore's Johns Hopkins University found it can be safe to delay surgery. The risk of noncurable prostate cancer was the same for men waiting two years for surgery as for those who had surgery immediately, researchers said."
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Prostate Cancer Screening Treatment Questioned
"NEW YORK (Reuters Health) - Men who receive prostate cancer screening and treatment do not appear to gain a survival benefit compared to men who do not undergo screening and treatment, study findings show.
The report, which is published in the October 5th issue of the British Medical Journal, adds to the ongoing debate on the value of prostate cancer screening.
Regardless, many men believe that screening is beneficial and would recommend the procedure, according to a second study in the same issue.
Currently, the American Cancer Society recommends annual prostate specific antigen (PSA) testing and a rectal exam beginning at age 50--and at age 45 for African Americans and men with a family history of the disease, who face a higher risk. Several other scientific and medical groups do not recommend routine prostate cancer screening.
Unlike other types of cancer, some prostate cancers can be slow growing and may never threaten the patient's life. Some say screening for prostate cancer using a PSA test may lead to unnecessary treatments--with side effects such as impotence and incontinence--by detecting cancers that are not life threatening.
In the current investigation, lead author Dr. Grace Lu-Yao of the University of Connecticut Health Center in Farmington and colleagues evaluated screening, treatments and deaths from prostate cancer among two different groups--94,900 men in Seattle, Washington and 120,621 men in Connecticut.
The PSA testing rate was 5.4 times higher for the men living in Seattle between 1987 and 1990 compared with men living in Connecticut, and the biopsy rate was more than double for the Seattle men compared to the Connecticut men in that time, the authors report.
This time period is considered the "early PSA era" and offers a unique opportunity for researchers to compare prostate cancer outcomes between different regions of the country that, at the time, had different approaches to PSA screening.
When the researchers assessed prostate cancer treatments between 1987 and 1996, they found that men in the Seattle group were about five times more likely to have their prostate removed. And, 3.9% of the Seattle group underwent radiation treatment compared to 3.1% of the men from Connecticut.
Despite the more intensive screening and treatments that took place among the Seattle group, the number of men who died from prostate cancer in the two groups over the total 11-year study period was nearly equal.
"The lack of association between more intensive screening and treatment and lower prostate cancer mortality suggests that trials should continue in order to settle this question," the researchers conclude.
In a second study, Alison Chapple and colleagues at the University of Oxford, UK, interviewed 52 British men suspected or confirmed to have prostate cancer about their beliefs about prostate cancer screening.
While the bulk of the men reported that they would recommend that others get a PSA test, four of the men in the group told the investigators that they were against national screening for prostate cancer.
For the most part, men in the "pro-screening" camp felt that early detection would improve their chances of recovery--despite the lack of scientific evidence supporting such a stance--or they thought that screening was a medically responsible thing to do.
"Doctors, policymakers and politicians need to understand why people want wider access to PSA testing, so they can find better ways of communicating information about risk," Chapple and colleagues conclude.
PSA is a protein produced by the prostate gland. PSA levels above 4 nanograms per milliliter (ng/mL) of blood can signal prostate cancer, but not always--sometimes a rise in PSA is due to another cause, and sometimes cancer can occur without a rise in PSA. About 20% of aggressive prostate tumors are found in men with normal PSA levels."
SOURCE: British Medical Journal 2002;325:737-742.
PSA Testing: It Was Medical Gospel, but It Wasn't True
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New Test May Reduce Need For Some Prostate Cancer Biopsies
"BALTIMORE, MD -- May 19, 1998 -- A new prostate specific antigen (PSA) test that measures the percentage of free PSA in the blood not bound to other proteins could spare up to 200,000 men a year in the United States the pain, anxiety and inconvenience of a surgical biopsy to detect cancer." Read the entire article at:
Doctor's Guide - New Test May Reduce Need For Some Prostate Cancer Biopsies
What is the Prostate Specific Antigen (PSA) Test and Free PSA
"PSA is a protein manufactured in the prostate and virtually no other organ. Women, who lack prostates, do not have detectable levels of PSA. Actually, PSA is the enzyme responsible for liquifaction of semen a few minutes after it has clotted. The prostate glands manufacture this protein in large quantities." Read the entire article at:
Prostate Specific Antigen (PSA)
Researchers find better predictor of prostate cancer risk
By Tim Friend, USA TODAY, 08-25-2003
Test identifies aggressive tumours
"A simple test can be used to identify patients with the most aggressive prostate cancers.
Researchers say it is so sensitive it can even differentiate between patients whose tumours are at the same stage. At present the degree to which prostate cancers have progressed is determined by the Gleason grading system, which is based on the shape and microscopic appearance of tumours.Patients with higher grades of tumour are in more advanced stages of the disease, but the grade does not tell how aggressively the tumours have been growing or stimulating the development of secondary growths. Prostate cancer is set to become the most common male cancer by 2006, as lung cancer rates fall and the population ages.
On the increase
Incidence of the cancer has been rising steadily over the last 30 years. It now affects around 22,000 men in the UK each year and is fatal for around 10,000.
The Gleason grading system assigns tumours a score between two and 10, with 10 being the most advanced cancer. Patients with a Gleason score from seven to 10 have a higher risk of dying of prostate cancer than those with lower scores, but some patients with higher scores outlive some with lower scores. This means that within any score, there are biologically aggressive and less aggressive forms of cancer. This makes it more difficult to predict outcomes for individual patients.
Enzyme clue
The new test, developed by Professor Akhouri Sinha, of the University of Minnesota, works by measuring concentrations of two important chemicals. One, an enzyme called cathepsin B (CB), helps cancer cells to invade surrounding healthy tissue. The other, called stefin A, blocks the action of cathepsin B. The researchers analysed tissue samples from 97 prostate cancer patients and eight patients with a benign enlargement of the prostate. They found that the level of cathepsin B relative to the level of Stefin A was significantly higher in patients whose cancer had spread.
Professor Sinha said: "The ratio of CB to stefin A reveals differences in tumours that are not visible under the microscope. "If this test were done on tumours of newly diagnosed patients, we would have an indication of which cancers were most aggressive, and we could give those patients aggressive treatment. Professor Sinha said the same approach could also be used for breast and colon cancer.
Reaction
Dr Charlotte Bevan, of the Prostate Cancer Charity, said: "This is a very exciting development as it could aid physicians in determining what level of treatment would be best for a given patient. "As cancer therapy itself can be very aggressive and exhausting for a patient and produce undesirable side-effects, any test that identifies cases where therapy can be minimised or made less aggressive is going to significantly improve the lives of these patients and their friends and families."
Dr Sara Hiom, a science information officer at the charity Cancer Research UK, said scientists around the world were trying to find a way to pinpoint which prostate cancer tumours were potentially fatal, and which did not require intensive treatment. "We would welcome any accurate test that could distinguish between aggressive and indolent types of prostate cancer. We await results of further studies with great interest."
UK scientists from the Institute of Cancer Research recently announced a major initiative designed to find ways to differentiate between prostate tumours. Dr Chris Parker told BBC News Online that the US study showed promise in one particular field, that of identifying molecular differences between tumours. The UK effort will also focus on differences in the blood supply and oxygen supply between tumours as well as testing thousands of potential molecular markers.
The research is published in the journal Cancer."
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General Prostate Information and References
Enlarged Prostate - Benign Prostatic Hyperplasia
The Merck Manual - Benign adenomatous hyperplasia of the periurethral prostate gland, causing variable degrees of bladder outlet obstruction.Enlarged Prostate (Benign Prostatic Hypertrophy)
Intelihealth: Harvard Medical School - Symptoms, diagnosis and treatment.Main Menu of The Prostate Cancer InfoLink site (preserved at Phoenix5)
Very Informative Web Site.Clinical Staging, from the Prostate Cancer InfoLink site (preserved at Phoenix5)
Gives a detailed explanation of the different stages of prostate cancer.From Phoenix5's Prostate Cancer Glossary
Describes the Gleason Score for determining the cancer stage.The Prostate Cancer InfoLink
Links to many resources about prostate health.Prostate Cancer Therapy Hampers Sex Life
Men who take hormonal therapy to treat early-stage prostate cancer are twice as likely to suffer sexual problems than men who forgo treatment, according to a new study.Ultrasound Zaps Prostate Cancer
Men with prostate cancer may soon have a new, less invasive treatment option that promises fewer side effects.Genes 'determine prostate cancer'
A man's genetic make-up could have a direct bearing on his chance of developing prostate cancer, scientists have found.Gene fingerprint could spot cancer
Scientists may be one step closer to gaining the ability to "fingerprint" prostate cancers - spotting which are the most likely to spread.Facing Prostate Cancer, but How?
It is, of course, prostate cancer. And the dilemma for the growing number of men whose tumors are found when they are small and confined to the prostate is what to do about it.
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Selenium and Vitamin E May Significantly Reduce the Risk of Prostate Cancer
Vitamin E must be the natural, mixed-tocopherols type. Synthetic Vitamin E is actually unhealthy.
"In addition to selenium, Vitamin E also plays a prominent role in a new study on how selenium supplements may help prevent prostate cancer. Most selenium supplements sold are mixed with Vitamin E, and experts say the two appear to work together against cancer. Vitamin E's role as an antioxidant was highlighted this week when the Journal of the National Cancer Institute published results of a major new study of prostate cancer and selenium.
Researchers studied 33,000 men taking part in a health study that started in 1987; by 1994, 181 of the men had developed prostate cancer. The new report's authors, Philip Taylor and Demetrius Albanes of the National Cancer Institute, said their study suggested a sharp reduction in prostate cancer risk for men with a high intake of selenium. The reduction can range from one-half to two-thirds, the researchers reported.
Scientists are encouraged by new studies suggesting that antioxidants, such as Vitamin E, can play a preventive role against forms of cancer. The National Cancer Institute authors, Taylor and Albanes, noted that both selenium and Vitamin E work as antioxidants, but said there is uncertainty about how the antioxidants affect tumors." Read the entire article at:
Selenium and Vitamin E May Reduce the Risk of Prostate Cancer
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Eating Fatty Fish May Slash Risk Of Prostate Cancer
"New York, June 1, 2001 (PSA Rising) -- Consumption of fatty fish such as salmon, sardines, herring and mackerel could reduce the risk of prostate cancer by a third, according to a report in June 2 issue of The Lancet.
Essential fatty acids -- especially omega-3 fatty acids contained in large amounts in fatty fish -- have previously proved to inhibit the growth of prostate cancer cells." Read more about Omega-3 fatty acids at:
WebMD - Go Fish! Types High in Fatty Acids May Prevent Prostate Cancer
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Prostate Cancer Risk and Diet
"MAASTRICHT, THE NETHERLANDS. Many studies have attempted to find an association between prostate cancer risk and diet. Some studies have found an increased risk with high intakes of animal products and calcium, others have been inconclusive. Researchers at Maastricht University have just released the results of a major study regarding diet and prostate cancer risk. The study was part of the Netherlands Cohort Study which involves 58,279 men aged 55 to 69 years when they enrolled in the study in September 1986. The men completed a 150-item food frequency questionnaire at the beginning of the study period and also provided detailed information relating to other potential risk factors for cancer. After 6.3 years of follow-up 642 of the men had developed prostate cancer. The diet of these men was compared to that of 1525 men without prostate cancer. The researchers concluded that the overall consumption of fresh meat and poultry, fish, cheese, and eggs showed no correlation with prostate cancer risk. Consumption of whole yogurt was associated with a decreased risk, but no correlation was found between calcium intake and prostate cancer risk. There was some indication that certain cured meats (eg. sausages) were associated with an increased risk.
Schuurman, A.G., et al. Animal products, calcium and protein and prostate cancer risk in the Netherlands Cohort Study. British Journal of Cancer, Vol. 80, No. 7, June 1999, pp. 1107-13." Other studies claim the opposite:
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Are all cases of prostate cancer equal in risk?
"Bluntly, no they aren't. One of the most infuriating problems is that for many men a diagnosis of prostate cancer is not significant! If you look at the prostates taken from 100 American men over 50 years old who die in car crashes and similar accidents, that is men who never showed any clinical sign of prostate cancer while they were alive, you can, in fact, find small areas of cancer in the prostates of about 30 of those men (30%). Those men could have lived for years with those small areas (foci) of prostate cancer -- or some of them could have been diagnosed with clinically significant prostate cancer just a few months later if they had lived. If you do the same thing with American men over 90 years old, you find that 90% of them have microscopic evidence of prostate cancer.
These small areas of prostate cancer tissue that do not develop into clinically important disease are often called "latent" prostate cancer. For an average American man of 50 years of age, with a reasonable life expectancy of another 25 years, the chance that he will develop a microscopic focus of so-called "latent" prostate cancer tissue is estimated to be 42% (that is, 42 of 100 such men will get such a microscopic focus). However, the chance that the same man will get clinically significant prostate cancer (that is, prostate cancer that is associated with clear signs or symptoms of the disease) is only 9.5%. Finally, of the same 100 men, only about three will actually die of prostate cancer. So you can clearly see that while many men may get prostate cancer, it will actually affect relatively few of them very seriously. It is often said that most men are much more likely to die with prostate cancer than because of this disease.
We do not yet know how to tell which men with a small focus of prostate cancer are most likely to go on to get clinically significant disease. This is one of the most important things to understand about prostate cancer. It affects almost everything about the disease. It is something you should think about and discuss with your doctor before you ask to have specific tests for prostate cancer and most certainly before you receive treatment for early stages of prostate cancer which are confined to the prostate. You may be better off not having the specific tests if you have absolutely no reason to believe you are at risk for prostate cancer. And even if you are diagnosed with a small focus of cancer confined to the prostate, you may be better off if the doctor practices so-called watchful waiting rather than attempting curative therapy. You and your doctor need to make decisions like this together, and you should ask your doctor for all the information he or she can give you before you take those decisions." Read the entire article at:
"July 2, 2002 Many men over 60 are receiving unnecessary surgery and other treatments for prostate cancer even though the disease is unlikely to progress far enough to cause health problems, according to one analysis." Read the entire article at:
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High Calcium Intake May Increase Risk Of Prostate Cancer
"DAVIS, CA ---September 21, 2001 -- According to a new study in the American Journal of Clinical Nutrition, the risk of prostate cancer in men may increase with calcium intake, especially from dairy products.
As part of the Physicians' Health Study, Dr. Chan et al. investigated the connection between dairy product and calcium consumption and prostate cancer in a large group of male physicians in the United States. Compared with the men who consumed less than .5 serving of dairy products daily, men who consumed more than 2.5 servings had a 34 percent higher risk of developing prostate cancer.
The study group of 20,885 male physicians completed self-administered questionnaires concerning diet and lifestyle between 1982 and 1995. During 11 years of follow-up, 1012 incidents of prostate cancer were reported. The investigators created a dairy score for each participant by summing up the daily calcium contributions from each of five common dairy foods.
Men in the highest quintiles of dairy product consumption had a significant, 34 percent greater risk of prostate cancer when compared to those in the lowest categories. When calcium intake was examined apart from dairy product consumption, the risk ratio was 30 percent higher for advanced prostate cancer and 47 percent higher for non-advanced cases.
Of the dairy products consumed by the participants, only skim milk was individually positively associated with prostate cancer risk, perhaps because it accounted for 48 percent of total consumption of dairy foods.
The authors propose that dietary calcium increases prostate cancer risk by suppressing the production of 1,25-dihydroxyvitamin D3, the most active form of vitamin D, which is thought to protect against this disease. Examination of vitamin D metabolites in a subset of the study population revealed that those with the highest quintile of calcium consumption (>600 mg/day) had 17 percent lower serum concentrations of 1,25-dihydroxyvitamin D3 than those in the lowest quintile of calcium consumption ( £ 150 mg/day). Although the study did not address supplemental calcium consumption, previous studies limited to supplements have demonstrated similar risk ratios."
The authors conclude that, "These findings may serve to interject a note of caution into the current enthusiastic promotion of a higher intake of calcium in the United States."
Prostate Cancer and Milk - The overwhelming majority of research suggests strongly that increased milk consumption is associated with increased risk for prostate cancer.
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An Easier Way to Diagnose, Track Prostate Cancer?
New Test Almost 100% Accurate, Researchers Say
By Liza Jane Maltin
WebMD Medical News"May 1, 2000 (Atlanta) -- Researchers have discovered a new marker that may soon make prostate cancer diagnosis as quick and easy as a simple urine test.
The tool currently used for detecting prostate cancer -- PSA, or prostate specific antigen, testing -- is woefully inadequate, says lead researcher Mark Stearns, PhD. Not only does the test require a blood sample, it's not very accurate. "At least 25% of patients with cancer show up negative for PSA," he tells WebMD. And patients with benign, or non-cancerous, prostate problems often test positive for PSA.
So Stearns and his team at Medical College of Pennsylvania in Philadelphia "attempted to develop a better, less-invasive [test]. We were able to identify a marker that is present in the urine of patients with cancer but not in patients with benign disorders," he says. They presented their findings here Monday at a meeting of urology experts.
First, the researchers performed tests on cancerous and non-cancerous prostate tissue. They tested more than 4,000 substances and identified what seems to be a new marker that appears only in cancerous tumors. This new marker is a protein called prostate specific transcription factor (PSTF-1).
Next, they developed a simple urine test that doctors could use to screen patients for the marker. When they tested urine samples from more than 200 patients with cancer or benign prostate disease, they found that the test provided very accurate results. One hundred percent of the positives were from patients who had cancer, and nearly all of those with negative urine tests had no cancer.
Even more important, says Stearns, unlike PSA testing, the amount of PSTF-1 in the urine was a strong indicator of how severe the patient's cancer was. This means that the test could eventually be used to see whether prostate cancer treatment is working." Read the entire article at:
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Prostate Cancer Alternative Treatments
"To make any sense of this handout, you must already understand that the diagnosis of prostate cancer has been made, and that the additional studies and scans suggest that no spread of the cancer from the prostate has occurred. Assuming these studies to be accurate, any treatment that can control the cancer in the prostate, will therefore control all the cancer. The following are the choices that are available to us in the treatment of localized prostate cancer (Stage B)."
Prostate 'smart-bombing' to fight cancer.
Australia's first large study of a prostate cancer treatment described as "smart bombing" shows the therapy prevents the disease spreading in 90 per cent of cases and has minimum side-effects. Researchers say the results show the treatment, known as radiotherapy, should be offered more widely for prostate cancer patients. High dose rate radiotherapy (HDRB) directs intense radiation into affected parts of the prostate through hollow wires, minimizing damage to surrounding tissue. Urologist Phil Stricker, whose study is published in the latest Australasian Radiology journal, said HDRB was more precise than the "carpet-bombing" approach of conventional radiation therapy. In conventional radiation therapy external beams are directed at the patient, with the risk of radiation spilling over into healthy areas.
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Prostate Cancer Cure
THERAPY OF PROSTATE CANCER - August 1997 - Read Article No. 18
"18
UI - 97322736
AU - Shukla SK; Limouris GS; Cusumano R; Acconcia A; Cipriani C; Atzei G; Argiro G; Boemi S
TI - Advanced prostate cancer diagnosis and therapy with gallium-67 and yttrium-90, respectively.
SO - Anticancer Res 1997;17(3B):1731-4
AD - Servizio di Medicina Nucleare, Ospedale S. Eugenio, Roma, Italy.BACKGROUND: Androgen deprivation therapy remains so far the mainstay of advanced prostate cancer treatment. Although it improves the quality of life of the patient for some time, the disease progresses and soon it becomes hormonally unresponsive. The object of our research has been to find a systemic therapy for prostate cancer patients whose disease no longer responds to hormone therapy, radiation therapy, chemotherapy and immunotherapy.
PATIENTS AND METHODS: Thirty-one advanced prostate cancer patients with intense bone metastasis pain, bed ridden, and with permanent urinary catheter were first examined with Ga-67 and then treated with Y-90 solutions which were chromatographically and electrophoretically analysed for the presence of both cationic and anionic species of the radionuclid- e. The quality of life and prostate specific antigen (PSA values) values were followed for testing the success of the therapy.
RESULTS: Prostate cancer-affine Y-90 cured the advanced prostate cancer patients who regained their normal life. The uptake of the radionucl- ide in the primary cancer and its metastases responsible for the treatment has been confirmed by scintigraphy.
CONCLUSIONS: Prostate cancer-affine Y-90 solution, containing stable cationic and anionic species of the radionuclide, is effective in the cure of advanced prostate cancer patients."
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DHEA Protects Against Prostate Cancer
"We do not usually report information based on animal experiments; however, the finding that DHEA can prevent or even reverse prostate cancer in laboratory rats seemed important enough to make an exception.
CHICAGO, ILLINOIS. Prostate cancer is the second most common cause of cancer death in Western male populations. It is estimated that about 18 per cent of American men will develop prostate cancer during their lifetime. Some researchers believe that many more have the beginnings of prostate cancer, but die from other causes before the cancer becomes invasive and fatal. Research has shown that the hormone DHEA (dehydroepiandrosterone) inhibits the growth of both human and rat prostate cancer cells in vitro (in test tubes). Now a team of researchers from the National Cancer Institute, the New York University School of Medicine, and the ITT Research Institute reports that DHEA confers significant protection against prostate cancer progression when given to laboratory rats as part of their diet. Their experiment involved rats which were given carcinogenic chemicals to induce precancerous lesions in the prostate. One group of rats had 1000 or 2000 mg of DHEA added to each kilogram of feed starting one week before inducing the cancer. Other groups had 2000 mg of DHEA added per kilogram of diet one week before induction, 20 weeks after induction or 40 weeks after induction. The rats received the DHEA until the experiment was concluded 13 months after cancer induction. Control rats received no DHEA. The researchers found a very significant decrease in the progression to full prostate cancer among the rats given DHEA in their diets. This effect was evident whether the DHEA was given one week before or 20 or 40 weeks after cancer induction. They conclude that DHEA or a suitable derivative may be effective in preventing the development and progression of prostate cancer in humans, but caution that more work is required to ensure the DHEA's hormonal effects (conversion to testosterone and estrogenic activity) are not detrimental.
Rao, K.V.N., et al. Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Research, Vol. 59, No. 13, July 1, 1999, pp. 3084-89." Read the entire article at:Note: DHEA converts to testosterone and may convert to dihydortestosterone (DHT) which is suspect in causing prostate cancer. The DHEA may increase PSA test results. Natural progesterone and Omega-3 fatty acids may prevent the testosterone from converting to DHT and thereby reduce the cancer risk.
News About Prostate Health
Caution on cancer exercise link - BBC News - April 14, 2008.
"The US study found tumours expanded twice as fast in mice given exercise wheels compared to those without."
"Researchers from the University of California at Los Angeles and Duke University have reported that androgen deprivation therapy (ADT) increases cardiovascular morbidity and could impact survival in men with low-risk prostate cancer. The details of this study appeared in an early on-line publication in Cancer on July 26, 2007."
"ADT is commonly used as palliative therapy for patients with advanced prostate cancer. The main side effects include: loss of libido, weight gain, osteoporosis, fractures, and anemia. ADT is also an alternative for the treatment of early stages of prostate cancer, especially for older patients with significant co-morbidities. However, the long-term effects of prolonged ADT for treatment of early prostate cancer are poorly defined. Patients with prostate cancer frequently die of cardiovascular disease and the impact of ADT therapy on cardiovascular morbidity and mortality is not well defined."
New test pinpoints deadliest prostate cancers - July 20, 2007.
"LONDON (Reuters) - Scientists have found a new way to identify a particularly deadly form of prostate cancer in a breakthrough that could save tens of thousands of men from undergoing unnecessary surgery each year. In contrast to many cancers, only certain prostate tumors require treatment. Many are slow-growing and pose little threat to health. But separating the "tigers" from the "pussycats" -- as oncologists dub them -- is tricky. "Many people get treated radically but probably two-thirds of them never needed treating," he added. Radical prostate surgery often causes debilitating side effects such as impotence and incontinence, so any system that minimizes treatment would be a major boon to quality of life."
"Researchers knew that prostate cancers commonly contain a fusion of the TMPRSS2 and ERG genes, but the new study found that in 6.6 percent of cases this fusion was doubled up, creating a deadly alteration known as 2+Edel. Patients with 2+Edel have only a 25 percent survival rate after eight years, compared to 90 percent for those with no alterations in this region of DNA. "If you get two copies it's really bad news," Cooper said. Exactly how the duplication makes tumors more aggressive is not clear, though Cooper speculates it could result in higher expression of proteins needed to drive tumor growth or be a more general indicator of genome instability. Whatever the mechanism, 2+Edel is a clear-cut marker for risk that Cooper hopes will soon be used alongside existing techniques at the time of diagnosis to decide whether men require treatment."
Nanoparticulate Delivery of "Suicide DNA" to Murine Prostate and Prostate Tumors - May 23, 2007.
Using nanoparticles developed by members of the Alliance for Nanotechnology in Cancer, a team of investigators at the Lankenau Institute for Medical Research, in Philadelphia, has developed a DNA-based therapeutic agent that has the potential to treat both enlarged prostates and localized prostate tumors. When tested in mice, this new agent specifically targeted prostate tissue, producing no toxic effects in surrounding tissues.
Writing in the journal The Prostate, a team of investigators led by Janet Sawicki, Ph.D., described its use of polymer nanoparticles to delivery a so-called suicide gene that codes for the production of diphtheria toxin. The biodegradable and biocompatible polymer nanoparticles were developed by Robert Langer, Ph.D., and his colleagues at the MIT-Harvard Center of Cancer Nanotechnology Excellence.
To make their suicide gene specific for prostate tissue, the investigators linked it to a gene regulator that responds only in the presence of a prostate-specific protein. Without this protein, the diphtheria toxin gene remains inactive, which makes it non-toxic to any cells but those in the prostate.
When injected directly into the prostate, this nanoparticle-encapsulated gene construct triggered a significant reduction in the size of the prostate gland and on the size of prostate tumors. The investigators showed that this shrinkage resulted from cells undergoing apoptosis, or programmed cell death. In fact, the researchers found that a single injection of nanoparticles triggered apoptosis in 80 percent of tumor cells present in the tissue. In contrast, direct injection of the gene construct alone, that is, without the nanoparticle delivery vehicle, produced no effect on prostate tissue or tumors.
The investigators note that they expect multiple nanoparticle injections would trigger a greater percentage of prostate tumor cells to undergo apoptosis. They are now testing this hypothesis.
This work is detailed in a paper titled, "Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors." An investigator from the Harvard Medical School also participated in this study. An abstract of this paper is available through PubMed. View abstract.
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Quick, Innovative Procedure Helps Men Minimize Incontinence After Prostatectomy - May 12, 2007.
"Thousands of men facing surgical removal of the prostate due to cancer may someday have one less thing to worry about: post-surgical urinary incontinence. That's because a team of expert urologic surgeons at NewYork-Presbyterian Hospital/Weill Cornell Medical Center has devised a simple, effective means of reconstructing key anatomical structures that ensure continence. They describe the success of the procedure in the journal Urology."
This treatment with a 120-watt green light laser appears to shrink the prostate gland as described. However, cooking the prostate with 120-watts of power does not sound like a great idea. Placing 120-watts into such a small enclosed area should not be described as "gentle prostate therapy". The clinic does not list any of the side effects, of which many must be severe.
Dendreon stock triples on prostate cancer finding - March 30, 2007.
"BOSTON (Reuters) — Shares of Dendreon (DNDN) tripled Friday after an advisory panel to the U.S. Food and Drug Administration recommended approval of its experimental therapeutic cancer vaccine. Dendreon's Provenge is not a preventive vaccine to be given before the disease develops, but a therapeutic vaccine that is given once the disease has been diagnosed, to prevent its further progress.
Dendreon showed that its novel cancer therapy is reasonably safe and provided "substantial evidence" it benefits men with advanced prostate cancer, the panel ruled Thursday. Provenge is designed to stimulate the body's immune system to fight a diagnosed cancer.
Two Dendreon studies failed to meet their main goal of slowing the progress of advanced prostate cancer, but one analysis found patients treated with the product lived about 4.5 months longer."
This news report is not good news for men with prostate cancer. Men want a treatment to cure their cancer, not simply prolong life by an average of only 4.5 months. This is ridiculous. Living 4.5 months longer is next to worthless. Men do not want to die from prostate cancer. Many men will likely opt for this cancer treatment without knowing the insignificant benefit. Other treatments such as surgery or radiation have been shown to provide a lasting cure in many men. This more promising treatments should not be bypassed in favor of the Provenge treatment that only provides an average live extension of 4.5 months.
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Reference Books and Online Support Groups
Active Low-Carber Forums - Atkins & Low Carbohydrate Diet Support Group
You can talk with others who have bowel diseases or Candida about their experiences. Registration is free but is required before you can post your own message or question. You can click above to visit and read posts by others. Look for the "Candida Yeast & IBS" topic link.
Life Without Bread: How a Low-Carbohydrate Diet Can Save Your Life
Life Without Bread is an important addition to the growing body of literature on the benefits and importance of low-carb diet. Written by Christian Allan, Ph.D., and Wolfgang Lutz, M.D., the book is based on Dr. Lutz's experience using carbohydrate restricted diets with thousands of patients for more than 40 years. It is based on extensive research in the medical and scientific literature, and provides ample references. The book presents a unified theory of how high (and even "moderate") levels of dietary carbohydrate cause or exacerbate various health problems, and how carbohydrate restriction can help people to recover from those problems.
The book Life Without Bread by Christian Allan, Ph.D. and Wolfgang Lutz, M.D. has a chapter on gastrointestinal diseases. Don't be mislead by the title to believe the cure is the simple elimination of bread. Mr. Lutz's older book is out of print but has essentially the same information. It may even contain more detail than his new book above. Fortunately, Chapter VII: Gastro-Intestinal Tract of the older book can be read online.
Dr. Atkins' New Diet Revolution - Revised and Improved
The Atkins' New Diet Revolution is the best book for an initial dietary change and quick weight loss, reduced blood pressure and reduced cholesterol. Look for the companion book for recipes. It has some very interesting case studies from the doctor's patients. It includes data from past civilizations proving the low-carbohydrate diet is the most healthy.
Robert C. Atkins, M.D. ISBN: 006001203X.Dr. Atkins' Age-Defying Diet Revolution
This is Dr. Atkins newest book. The main topics are the cause, prevention and cure for diabetes and heart disease which have become major health concerns in the United States and many other developed countries.
Robert C. Atkins, M.D. with Sheila Buff ISBN: 0312251890.This book by Dr. Michael and Dr. Mary Dan Eades has an excellent chapter on "Leaky Gut Syndrome" which describes the cause of bowel diseases and autoimmune diseases.
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MEDICAL DISCLAIMER: All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. You should seek prompt medical care for any specific health issues and consult your physician before starting a new fitness or nutrition regimen. The information contained in this online site and email is presented in summary form only and intended to provide broad consumer understanding and knowledge of dietary supplements. The information should not be considered complete and should not be used in place of a visit, call, consultation or advice of your physician or other health care provider. We do not recommend the self-management of health problems. Information obtained by using our services is not exhaustive and does not cover all diseases, ailments, physical conditions or their treatment. Should you have any health care related questions, please call or see your physician or other health care provider promptly. You should never disregard medical advice or delay in seeking it because of something you have read here. We strongly suggest you select a physician who is knowledgeable and supportive of the low-carbohydrate diet. Many of the physicians listed on this page have health clinics.
Drugs and Doctors May be the Third Leading Cause of Death in U.S.
Why Most Published Research Findings Are False.
Pharmaceutical firms are inventing diseases to sell more drugs.
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Copyright © 2002 - 2007 by Kent R. Rieske, B.Sc., and Bible Life Ministries. All Rights Reserved.
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Prophecy Today for the Body of Christ![]()
God's Election & Man's Free Will
Are the Sins of All Mankind Forgiven?